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Indications
• Healing of Erosive or Ulcerative GERD
• Maintenance of Healing of Erosive or Ulcerative GERD
• Treatment of Symptomatic GERD
• Healing of Duodenal Ulcers
• Helicobacter pylori Eradication to Reduce the Risk of Duodenal Ulcer Recurrence
• Treatment of Pathological Hypersecretory Conditions, Including Zollinger-Ellison Syndrome
Pharmacology
By blocking the gastric H+/K+-ATPase at the secretory membrane of the gastric parietal cell, rabeprazole reduces gastric acid production. Rabeprazole has been classified as a gastric proton-pump inhibitor since this enzyme is thought to be the acid (proton) pump within the parietal cell.
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Dosage & Administration
Xorel-20 tablet should be swallowed whole. Xorel-20 tablet can be taken with or without food.
Healing of Erosive or Ulcerative GERD The recommended adult oral dose is Xorel-20 tablet to be taken once daily for four to eight weeks. For those patients who have not healed after 8 weeks of treatment, an additional 8-week course of Xorel-20 tablet may be considered.
Maintenance of Healing of Erosive or Ulcerative GERD The recommended adult oral dose is one Xorel-20 tablet once daily.
Treatment of Symptomatic GERD The recommended adult oral dose is one Xorel-20 tablet once daily for 4 weeks. If symptoms do not resolve completely after 4 weeks, an additional course of treatment may be considered.
Healing of Duodenal Ulcers The recommended adult oral dose is one Xorel-20 tablet once daily after the morning meal for a period up to 4 weeks. Most patients with duodenal ulcer heal within 4 weeks. A few patients may require additional therapy to achieve healing.
Treatment of Pathological Hypersecretory Conditions, Including Zollinger-Ellison Syndrome:
The dosage of Xorel-20 tablet in patients with pathological hypersecretory conditions varies with the individual patient. The recommended adult oral starting dose is 60 mg once a day. Doses should be adjusted to individual patients needs and should continue for as long as clinically indicated. Some patients may require divided doses. Some patients with Zollinger-Ellison syndrome have been treated continuously with Xorel-20 tablet for up to one year.
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