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Ciprocin Eye/Ear Drops
Generic Name:
Brand:
Indications
Ciprofloxacin is indicated for the treatment of Respiratory
Tract Infections,Urinary tract infections, Pelvic Inflammatory Diseases,
Infectious Diarrhea (Shigella dysenteriae, Vibrio cholera), Typhoid fever,
Intra-abdominal infections, Prostatitis, Skin and Soft Tissue Infections, Bone
and Joint Infections, Gonorrhea, Neutropenic patients with fever due to
bacterial infection, Meningitis, Surgical prophylaxis.
Therapeutic Class
4-Quinolone preparations, Anti-diarrhoeal Antimicrobial drugs
Pharmacology
Ciprofloxacin is a synthetic fluoroquinolone. It has
bactericidal activity against a wide range of gram-positive and gram-negative
organisms. It inhibits bacterial DNA synthesis by binding with the bacterial
enzyme-DNA gyrase and topoisomerase IV which are responsible for DNA
supercoiling.
Dosage
Tablet: Adult:
- Respiratory Tract Infections: 500 to 750 mg twice daily
(7 to 14 days)
- Urinary tract infections: 250 to 750 mg twice daily
(3 to 10 days)
- Pelvic Inflammatory Diseases: 500 to 750 mg twice daily
(14 days)
- Infectious Diarrhea (Shigella dysenteriae,
Vibrio cholera):
500 mg twice daily (1 to 5 days)
- Typhoid
fever: 500 mg twice daily (7 days)
- Intra-abdominal infections: 500 to 750 mg twice daily
(5 to 14 days)
- Prostatitis: 500 to 750 mg twice daily (2 to 6 weeks)
- Skin and Soft Tissue Infections: 500 to 750 mg twice daily
(7 to 14 days)
- Bone and Joint Infections: 500 to 750 mg twice daily
(max. 3 months)
- Gonorrhea: 500 mg as a single dose
- Neutropenic patients with fever due to
bacterial infection: 500 to 750 mg twice daily co-administered
with appropriate antibacterials.
- Meningitis: 500 mg as a single dose.
- Surgical prophylaxis: 500 mg as a single dose,
60 minutes before the procedure.
Suspension: Pediatric: 10-20
mg/kg (max. 750 mg) twice daily (10 to 21 days). The duration of therapy
depends on the type and severity of the infection.
Extended-release tablet: In uncomplicated urinary tract
infection (acute cystitis), the recommended dose of extended-release tablet is
1000 mg tablet once daily for three days.
For IV infusion:
- Urinary Tract Infection: Mild to Moderate: 200 mg
12 hourly for 7-14 days; Severe or Complicated: 400 mg 12 hourly for 7-14
days
- Lower Respiratory Tract infection: Mild to Moderate: 400 mg
12 hourly for 7-14 days; Severe or Complicated: 400 mg 8 hourly for 7-14
days
- Nosocomial Pneumonia: Mild/Moderate/Severe: 400
mg 8 hourly for 10-14 days
- Skin and Skin Structure: Mild to Moderate: 400 mg
12 hourly for 7-14 days; Severe or Complicated: 400 mg 8 hourly for 7-14
days
- Bone and Joint Infection: Mild to Moderate: 400 mg
12 hourly for more than 4-6 weeks; Severe/Complicated: 400 mg 8 hourly for
more than 4-6weeks
- Intraabdominal (Acute abdomen): Complicated: 400 mg 12
hourly for 7-14 days
- Acute Sinusitis: Mild/Moderate: 400 mg 12
hourly for 10 days
- Chronic Bacterial Prostatitis: Mild/Moderate: 400 mg 12
hourly for 28 Days.
* চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন'
Administration
Instruction for the use of Ciprofloxacin IV infusion-
- Check
the bag for minute leaks by squeezing the inner bag firmly. If leaks are
found, or if seal is not intact, discard the solution.
- Do
not use if the solution is cloudy or a precipitate is present.
- Do
not use flexible bags in series connections.
- Close
flow control clamp of administration set.
- Remove
cover from port at bottom of bag.
- Insert
piercing pin of administration set into port with a twisting motion until
the pin is firmly seated.
- Suspend
bag from hanger.
- Squeeze
and release drip chamber to establish proper fluid level in chamber during
infusion of Ciprofloxacin IV infusion.
- Open
flow control clamp to expel air from set.Close clamp.
- Regulate
rate of administration with flow control clamp
Duration of treatment: The duration of
treatment depends upon the severity of infection, clinical response and
bacteriological findings. For acute infections the usual treatment period is 5
to 10 days. Generally treatment should be continued for 3 days after the signs
and symptoms of the infection have been disappeared.
* চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন'
Interaction
Concurrent administration of Ciprofloxacin should be avoided
with Magnesium or Aluminum containing antacids or sucralfate or with other
products containing Calcium, Iron or Zinc. These products may be taken two
hours after or six hours before Ciprofloxacin. Ciprofloxacin should not be
taken concurrently with milk or other dairy products, since absorption of
Ciprofloxacin may be significantly reduced. Dietary calcium is a part of a
meal, however, does not significantly affect the absorption of Ciprofloxacin.
Contraindications
It is contraindicated in patients who have known
hypersensitivity to Ciprofloxacin or other quinolones.
Side Effects
Side effects include- nausea and other gastrointestinal
disturbances, headache, dizziness, joint pain and skin rashes.
Pregnancy & Lactation
There are no adequate and well-controlled studies in pregnant
women. Ciprofloxacin should be used during pregnancy only if the potential
benefit justifies the potential risk to the fetus and mother. Ciprofloxacin is
excreted in human milk. Due to the potential risk of articular damage,
Ciprofloxacin should not be used during lactation.
Precautions & Warnings
Patients receiving Ciprofloxacin should be instructed to drink
fluids liberally. It should be used with caution in patients with suspected or
known CNS disorders such as epilepsy or other factors which predispose to
seizures and convulsion. Avoid in patients with known QT prolongation,
hypokalemia.
Use in Special Populations
Although effective in clinical trials, Ciprofloxacin is not a
drug of first choice in pediatric population.
Overdose Effects
Overdose following Ciprofloxacin administration may lead to
seizures, hallucinations, confusion, abdominal discomfort, renal and hepatic
impairment as well as crystalluria, haematuria, & reversible renal
toxicity.
Storage Conditions
Keep below 30°C temperature, protected from light &
moisture. Keep out of the reach of children.
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